Optimal Duo

The ultimate health optimisation bundle that combines genetic insights and microbiome analysis for better health, resilience and longevity.

  • At-home test
Sample
Mixed
Collection
At-home cheek swab, posted to the lab + at-home stool sample, posted to the lab
Results in
10–25 days
Biomarkers
110
Doctor reviewed
No
Tests for
  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • +48 more

Test specifications

Provider
Stride
Sample type
mixed
Collection method
at-home cheek swab, posted to the lab + at-home stool sample, posted to the lab
Turnaround time
10–25 days
Biomarkers tested
110
At-home test
Yes
Doctor reviewed
No
Gender focus
Both

What's tested

60 biomarkers as listed by Stride, of 110 in total.

Methylation

  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • MTR
  • MTRR
  • PEMT
  • SOD2ORA2A
  • TCN2
  • VDR

Nutrition

  • ACE
  • ADH1C
  • ADRB2
  • AGT
  • ALDOB
  • APOA2
  • APOA5
  • APOC3
  • APOE
  • BCMO1
  • BCO1
  • CAT
  • CBS
  • CETP
  • CLOCK
  • CYP1A2
  • CYP4F2
  • EPHX1
  • FABP2
  • FTO
  • GPX1
  • GSTT1
  • HFE
  • HLA DQ2/DQ8
  • IL6
  • INSIG
  • LCT/MCM6
  • LEPR
  • LIPC
  • LPL
  • MC4R
  • NBPF3
  • PLIN
  • PPARG
  • SLC23A1
  • SOD2
  • TCF7L2
  • TF
  • TFR2
  • TMPRSS6
  • TNF
  • ZPR1

About this test

Combined DNA and gut microbiome test

Over 40 optimal DNA reports alongside our advanced gut health test, all from the comfort of your home

Optimal Duo: Optimal DNA & Methylation Health reports + gut health, gut-brain axis, digestion and metabolic health reports.

The ultimate health optimisation bundle that combines genetic insights and microbiome analysis for better health, resilience and longevity.

  • Comprehensive DNA reports covering methylation profile, nutrition, fitness, sleep and stress, and skincare genetic insights
  • Detailed gut health analysis covering overall microbiome health, digestive health, gut-brain axis, and metabolism insights
  • Includes a complimentary 1:1 consultation with a Stride dietetics expert

Key benefits

Double the insights, one seamless experience

Get a comprehensive view of your health with combined DNA and gut microbiome analysis - all in one package.

Personalised answers for your whole body

Understand how your genes and gut bacteria influence everything from metabolism, digestion, sleep, and stress to energy, immunity, and cognitive performance.

Tailored action plan + expert support

You'll review your results with a Stride expert in a complimentary video consultation - translating your genetics and gut health into clear, actionable recommendations across nutrition, lifestyle, and supplements.

Comprehensive DNA Testing

StrideDNA, our advanced at-home DNA test, analyses 9,000 essential genetic locations and 110 key genes, generating over 40 personalised genetic reports, covering:

  • Methylation Profile: Understanding your genetic capacity for key biological processes (e.g. Folate cycle and the MTHFR gene)
  • Diet & Nutrition: Personalised insights into your optimal diet, food sensitivities and micronutrient needs (e.g. Carb/fat sensitivities, vitamin B needs, lactose tolerance)
  • Fitness & Recovery: Exercise response and recovery optimisation markers (e.g. Power vs endurance, aerobic trainability, injury risk)
  • Sleep & Stress: Genetic factors affecting your rest and resilience (e.g. Chronotype, sleep quality, stress resilience)
  • Skin Health: Your genetic predisposition to various skin conditions and optimal care (e.g. Skin ageing, oxidative stress, pigmentation)

Each report includes practical, personalised recommendations to help you optimise your health based on your genetic profile.

Advanced Microbiome Testing

StrideBiome, our in-depth at-home microbiome test, analyses your unique gut bacteria composition using next-generation sequencing technology, providing insights into:

  • Overall Gut Health: Understanding your microbiome diversity and beneficial bacteria balance (e.g. Microbiome health score, diversity index, bacterial richness and balance)
  • Digestive Function: Analysis of your digestive efficiency and nutrient absorption (e.g. Short-chain fatty acid production, gut barrier health, vitamin synthesis)
  • Gut-Brain Axis: The connection between your microbiome and mental wellbeing (e.g. Serotonin pathways, GABA production, dopamine synthesis)
  • Metabolic Health: Impact on your body's energy and weight management (e.g. Bacteroidota:Bacillota ratio, proteobacteria levels, metabolic markers)

Each report includes science-backed recommendations to help you nurture a healthier gut microbiome through targeted nutrition and lifestyle optimisation.

Expert Health Consultation

Your bundle includes a personalised consultation with one of our dietetics experts to help you:

  • Interpret your results: Deep-dive into your DNA and microbiome reports to understand your unique health profile
  • Create your action plan: Develop a tailored nutrition and lifestyle strategy based on your genetic and gut insights
  • Optimise your supplements: Fine-tune your supplement regime to match your body's specific needs
  • Answer your questions: Get expert clarity on your results and recommendations in a one-to-one session

Our in-house experts specialise in personalised nutrition and can help translate your genetic and microbiome insights into practical, achievable changes for optimal health.

Description provided by Stride.

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Optimal DNA & Methylation Test

Methylation and nutrition in full, plus sleep, stress, skin and fitness. The Stride DNA & Methylation Test shows how efficiently your body methylates and uses key nutrients like folate and other B vitamins, with insight into genes such as MTHFR, MTR, MAOA and COMT.

  • At-home test
9.0 / 10 Best for broad methylation genetics

Methylation Stack

Optimal DNA & methylation test including 46 reports, plus 3 months' supply of MS-01, our methylated B vitamin complex. Unlock your methylation blueprint + daily support.

  • At-home test
8.6 / 10 Best for testing plus support bundle